Fat redistribution: May cause redistribution of fat eg, buffalo hump, peripheral wasting with increased abdominal girth, cushingoid appearance. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Certain medicines may prevent or dissolve uric acid stones. Triazolam: Protease Inhibitors may increase the serum concentration of Triazolam. Before giving you any new medicine, how often did hospital staff tell you what the medicine was for?
For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. Who should not take Crixivan? How should I store ONGLYZA? Known hypersensitivity to indinavir or any ingredient in the formulation.
Indinavir may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away. Ado-Trastuzumab Emtansine: CYP3A4 Inhibitors Strong may increase serum concentrations of the active metabolites of Ado-Trastuzumab Emtansine. Specifically, strong CYP3A4 inhibitors may increase concentrations of the cytotoxic DM1 component. Everolimus can make you more likely to get infections or may worsen any current infections. Therefore, well to prevent the spread of infection.
Luvox to treat obsessive-compulsive disorder. American Thoracic Society ATS and Centers for Disease Control and Prevention CDC. Targeted tuberculin testing and treatment of latent tuberculosis infections. Am J Respir Crit Care Med. Use with caution. May make these conditions worse. What are the possible side effects of Crixivan?
This has been shown to decrease the risk of giving HIV to the baby. Indinavir may be part of that treatment. Discuss the risks and benefits with your doctor. Build up of acid in your blood lactic acidosis. Dose reduction of rifabutin to half the standard dose and a dose increase of Crixivan to 1000 mg every 8 hours are recommended when rifabutin and Crixivan are coadministered. Tasimelteon: CYP3A4 Inhibitors Strong may increase the serum concentration of Tasimelteon. Who should not take ONGLYZA? Yeh KC, Deutsch PJ, Haddix H et al. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents Chemother. Read the Patient Information Leaflet provided by your pharmacist before you start taking indinavir and each time you get a refill. If you have any questions, consult your doctor or pharmacist. To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports. Gerberding J. Is antiretroviral treatment after percutaneous HIV exposure justified? Let your doctor know if you have any unexplained muscle pain, tenderness, weakness, or discoloration of your urine. Your doctor may want to change your cholesterol medicine. Deyton L. Importance of surrogate markers in evaluation of antiviral therapy for HIV infection. JAMA. ONGLYZA will harm your unborn baby. Caucasian subjects consisting of six racial groups. Dispense in tight container as defined in USP. Cmax compared to 800 mg every 8 hours alone. Reboxetine: CYP3A4 Inhibitors Strong may increase the serum concentration of Reboxetine.
Dose reduction of Crixivan to 600 mg every 8 hours is recommended when administering ketoconazole concurrently. Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Which drugs or supplements interact with indinavir? Indinavir is used with other medicines to treat HIV infection. Take all other medicines your doctor has prescribed as part of your combination treatment. Your dose of indinavir may depend on the other medicines you are using. CRIXIVAN, an Antiretroviral Pregnancy Registry has been established. tinidazole
Cariprazine: CYP3A4 Inhibitors Strong may increase the serum concentration of Cariprazine. Management: Cariprazine dose reductions of 50% are required; specific recommended management varies slightly for those stable on cariprazine versus those just starting cariprazine. See prescribing information or full interaction monograph for details. Vilazodone: CYP3A4 Inhibitors Strong may increase the serum concentration of Vilazodone. Genentech USA. Invirase saquinavir mesylate capsules and tablets prescribing information. South San Francisco, CA; 2012 Feb. Indinavir is best taken with water on an empty stomach 1 hour before or 2 hours after a meal. Alternatively, it may be taken with other liquids or a light meal dry toast with jelly, juice, coffee with skim milk and sugar, or corn flakes with skim milk and sugar. It should not be taken with a high calorie, fat, or protein meal because absorption is reduced. Other medications can affect the removal of from your body, which may affect how indinavir works. Kopp JB, Miller KD, Mican JM et al. Crystalluria and urinary tract abnormalities associated with indinavir. Ann Intern Med. Cardiovascular System: cardiovascular disorders including myocardial infarction and angina pectoris; cerebrovascular disorder. Lovastatin: Protease Inhibitors may increase the serum concentration of Lovastatin. Meyers MW. Dear investigator letter regarding VIRAMUNE in combination with protease inhibitors. gamno.info alfuzosin
F. Do not freeze. Arminio Monforte A, Testa L, Gianotto M, Gori A, Franzetti F, Sollima S, Bini T, Moroni M "Indinavir-related alopecia. Budesonide Topical: CYP3A4 Inhibitors Strong may increase the serum concentration of Budesonide Topical. Management: Per US prescribing information, avoid this combination. Canadian product labeling does not recommend strict avoidance. If combined, monitor for excessive glucocorticoid effects as budesonide exposure may be increased. Adequate hydration recommended for all patients receiving indinavir. It is unknown if this medication passes into breast milk. Because breast milk can transmit HIV, do not breast-feed. Tipranavir: May decrease the serum concentration of Protease Inhibitors. ZERIT will not cure your HIV infection. Taking Crixivan with the above medications could result in serious or life-threatening problems such as irregular heartbeat or excessive sleepiness. Sustiva efavirenz US prescribing information.
Levobupivacaine: CYP3A4 Inhibitors Strong may increase the serum concentration of Levobupivacaine. The solution may appear slightly hazy. Store at room temperature away from moisture, heat, and light. Those who are dehydrated may be at increased risk and should be encouraged to consume additional amounts of liquid or given intravenous fluid if necessary. Fortovase saquinavir US prescribing information. Alosetron is used to treat severe, chronic irritable bowel syndrome IBS in women who have had diarrhea as the main symptom for at least 6 months. Alosetron should be used only in women who have tried other IBS treatments without success. Alosetron has not been shown to be effective in men with IBS. Comparison to historical data on 16 subjects receiving indinavir alone. Since this drug can be absorbed through the and and may harm an unborn baby, women who are or who may become pregnant should not handle this medication or breathe the dust from the tablets. Qaqish RB, Fisher E, Rublein J, Wohl DA "HIV-associated lipodystrophy syndrome. During pregnancy, this medication should be used only when clearly needed. However, it is now normal to prescribe HIV medicines for pregnant women with HIV. This has been shown to decrease the risk of giving HIV to the baby. Indinavir may be part of that treatment. Discuss the risks and benefits with your doctor. Take this medication by as directed by your doctor, usually once daily. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. Swallow this medication whole with a glass of water. Do not crush or chew the tablets. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Do not skip pills even if you do not have sex very often. Dose titration of ONGLYZA was not permitted during the study. Vardenafil: CYP3A4 Inhibitors Strong may increase the serum concentration of Vardenafil. asda fosamax
If you miss a dose, take it as soon as you remember unless it is more than 6 hours after the time you usually take the dose. In that case, skip the missed dose and resume your usual dosing schedule. Discard any unused portion after 30 days. Immune reconstitution syndrome has occurred during combination antiretroviral therapy. Patients responding to therapy may develop an inflammatory response to indolent or residual opportunistic infections and require evaluation and treatment. ARIPiprazole: CYP3A4 Inhibitors Strong may increase the serum concentration of ARIPiprazole. Management: See full interaction monograph for details. Praziquantel: CYP3A4 Inhibitors Strong may increase the serum concentration of Praziquantel. Moderate Be cautious with this combination. Patients with renal or hepatic impairment should not be given colchicine with CRIXIVAN. CYP3A4 Substrates: CYP3A4 Inhibitors Strong may decrease the metabolism of CYP3A4 Substrates. Exceptions: Alitretinoin Systemic; AmLODIPine; Buprenorphine; Gefitinib; HYDROcodone; Praziquantel; Telithromycin; Vinorelbine. Continue to take indinavir even if you feel well. Do not miss any doses. Tell your doctor if you notice changes in your body shape, such as an increased amount of fat in the upper back and neck, or around the chest and stomach area. You might also lose fat from the legs, arms, and face. Janssen Products LP. Olysio simeprevir capsules prescribing information. Titusville, NJ; 2013 Nov. L90M at which substitutions are associated with resistance, have been identified. Resistance was mediated by the co-expression of multiple and variable substitutions at these positions. cheap phenergan buy online pharmacy
This drug is used with other to help control infection. It helps to decrease the amount of HIV in your body so your can work better. This lowers your chance of getting HIV complications such as new infections, and improves your quality of life. Naldemedine: CYP3A4 Inhibitors Strong may increase the serum concentration of Naldemedine. ONGLYZA, ask your healthcare provider. In all clinical studies, with the exception of ACTG 320, the AMPLICOR HIV MONITOR assay was used to determine the level of circulating HIV RNA in serum. This is an experimental use of the assay. HIV RNA results should not be directly compared to results from other trials using different HIV RNA assays or using other sample sources. MiFEPRIStone: CYP3A4 Inhibitors Strong may increase the serum concentration of MiFEPRIStone. Large amounts of garlic may decrease the effectiveness of indinavir. Talk with your doctor before including garlic in your diet. Gagnon RF, Alli AI, Watters AK, Tsoukas CM "Indinavir crystalluria. Estazolam: CYP3A4 Inhibitors Strong may increase the serum concentration of Estazolam. What other drugs will affect alosetron Lotronex? Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Warnke D, Barreto J, Temesgen Z "Antiretroviral drugs.
Ribociclib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ribociclib. Management: Avoid use of ribociclib with strong CYP3A4 inhibitors when possible; if combined use cannot be avoided, reduce ribociclib dose to 400 mg once daily. Rachline A, Lariven S, Descamps V, Grossin M, Bouvet E "Leucocytoclastic vasculitis and indinavir. May lead to loss of virologic response and possible resistance to CRIXIVAN or to the class of protease inhibitors or other coadministered antiretroviral agents. It is against the law. Ibrutinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ibrutinib. Repaglinide: CYP3A4 Inhibitors Strong may increase the serum concentration of Repaglinide. Management: The addition of a CYP2C8 inhibitor to this drug combination may substantially increase the magnitude of increase in repaglinide exposure. When indinavir is taken with efavirenz, the beneficial effects of indinavir may decrease. Everolimus may rarely cause serious possibly fatal disease in people who have virus. Talk with your health provider. Indinavir pharmacokinetic parameters in these women were compared to those in HIV seropositive men pooled historical control data. Dose reduction of Crixivan to 600 mg every 8 hours should be considered. Paricalcitol: CYP3A4 Inhibitors Strong may increase the serum concentration of Paricalcitol. This helps indinavir work better. MEPRON, 3 reported rash 4%. Rash was not severe in any subject. Indinavir concentrations may be decreased in the presence of nevirapine. The appropriate doses for this combination, with respect to efficacy and safety, have not been established. Following single oral dose. cheap prinivil polo
Radotinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Radotinib. Ho DD. Time to hit HIV, early and hard. N Engl J Med. Zolpidem: CYP3A4 Inhibitors Strong may increase the serum concentration of Zolpidem. Concomitant use of Crixivan with lovastatin or simvastatin is contraindicated due to an increased risk of myopathy including rhabdomyolysis. Caution should be exercised if Crixivan is used concurrently with atorvastatin or rosuvastatin. Titrate the atorvastatin and rosuvastatin doses carefully and use the lowest necessary dose with Crixivan. What are the possible side effects of ONGLYZA? The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. Do not share it with other people. Always have another kind of birth control eg, condoms to use as a backup in case you miss pills. Also, always have an extra, full pack of pills. Dohme. Crixivan indinavir sulfate capsules prescribing information. Whitehouse Station, NJ; 2014 Jul. Deflazacort: CYP3A4 Inhibitors Strong may increase serum concentrations of the active metabolites of Deflazacort. Management: Administer one third of the recommended deflazacort dose when used together with a strong or moderate CYP3A4 inhibitor. AtorvaSTATin: Protease Inhibitors may increase the serum concentration of AtorvaSTATin. Management: See full monograph for recommended dose limits. Concomitant use of fluticasone propionate and Crixivan may increase plasma concentrations of fluticasone propionate. Use with caution. Consider alternatives to fluticasone propionate, particularly for long-term use. Advise patients that effective antiretroviral regimens can decrease HIV concentrations in blood and genital secretions and strict adherence to such regimens in conjunction with risk-reduction measures may decrease, but cannot absolutely eliminate, the risk of secondary transmission of HIV to others. Ulipristal: CYP3A4 Inhibitors Strong may increase the serum concentration of Ulipristal. Gulick RM, Mellors JW, Havlir D et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med. rizatriptan
Mild to moderate hepatic impairment due to cirrhosis: 600 mg every 8 hours. ONGLYZA and initiate appropriate management. Crixivan indinavir sulfate US prescribing information. Alosetron may also be used for purposes not listed in this medication guide. Changes in body fat fat redistribution. DPP4 enzyme within minutes. Buprenorphine: CYP3A4 Inhibitors Strong may increase the serum concentration of Buprenorphine. Crixivan is usually prescribed with other anti-HIV drugs such as ZDV also called AZT 3TC, ddI, ddC, or d4T. Crixivan works differently from these other anti-HIV drugs. Talk with your doctor about how you should take Crixivan. How should I take Crixivan?
The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Crixivan in combination with antiretroviral agents is indicated for the treatment of HIV infection. Valbenazine: CYP3A4 Inhibitors Strong may increase the serum concentration of Valbenazine. Management: Reduce the valbenazine dose to 40 mg daily when combined with strong CYP3A4 inhibitors. Perazella MA "Drug-induced renal failure: update on new medications and unique mechanisms of nephrotoxicity. Your doctor may adjust your dose if needed. Fauci AS. AIDS in 1996: much accomplished, much to do. JAMA. Saez-Llorens X, Ramilo O. Early experience with protease inhibitors in human immunodeficiency virus-infected children. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. This may not be a complete list of all interactions that may occur. Ask your health care provider if indinavir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. CDC 1982; some data suggests that benzoate displaces bilirubin from protein binding sites Ahlfors 2001; avoid or use dosage forms containing benzyl alcohol with caution in neonates. Talk to your doctor about any medications you are taking. Tolvaptan: CYP3A4 Inhibitors Strong may increase the serum concentration of Tolvaptan. Hirsch M, Steigbigel R, Staszewski S et al. A randomized, controlled trial of indinavir, zidovudine, and lamivudine in adults with advanced human immunodeficiency virus type 1 infection and prior antiretroviral therapy. J Infect Dis. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. The clinical significance of these gender differences in the pharmacokinetics of indinavir is not known. seroflo
II evaluation of the HIV protease inhibitor MK-639 indinavir. AIDS. Ivacaftor: CYP3A4 Inhibitors Strong may increase the serum concentration of Ivacaftor. Management: Ivacaftor dose reductions are required; consult full monograph content for specific age- and weight-based recommendations. Bosentan: Indinavir may increase the serum concentration of Bosentan. Bosentan may decrease the serum concentration of Indinavir. CRIXIVAN will exacerbate the hyperbilirubinemia seen in neonates. Antiretroviral therapy is not a cure for HIV infection; opportunistic infections and other complications associated with HIV disease may still occur. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night. For example, if you are to take three doses a day, the doses should be spaced about 8 hours apart. If you need help in planning the best times to take your medicine, check with your doctor.
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ZERIT cannot be ruled out. Administration with a substantial meal 48. L of water a day unless otherwise directed by your doctor. Must be taken with food. Domingo P, Barcelo M "Efavirenz-induced leukocytoclastic vasculitis.
The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using trazodone, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain problems , slow heartbeat, QT prolongation in the family history of certain heart problems QT prolongation in the EKG, sudden cardiac death. Impact of Antiretroviral Therapy. Sonidegib: CYP3A4 Inhibitors Strong may increase the serum concentration of Sonidegib. Your doctor may want to run some blood tests to see if your HIV therapy is still working.
Area under the curve over 24 hours. Alfuzosin: CYP3A4 Inhibitors Strong may increase the serum concentration of Alfuzosin. If you are taking indinavir with delavirdine and you notice any pain in your side, blood in your urine, nausea, vomiting, or diarrhea, contact your healthcare professional. If your doctor prescribes these medicines together, it may be necessary to adjust your dose of indinavir. Do not start, stop, or change the dosage of any medicine before checking with them first.
HIV-infected adults. AIDS Clinical Trials Group protocols 150 and 258. Ann Intern Med. Vindesine: CYP3A4 Inhibitors Strong may increase the serum concentration of Vindesine. Gulick RM, Mellors JW, Havlir D et al. Simultaneous vs sequential initiation of therapy with indinavir, zidovudine, and lamivudine for HIV-1 infection: 100-week follow-up. JAMA. Table 3 effect of indinavir on other drugs.